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  • Content Posted in 2008 | e-publications@RCSI | Royal College of Surgeons in Ireland Research
    Doyle Davida De La Harpe Hannah McGee Emer Shelley Michael Walsh and Kieran Daly PDF Cross sectional validation of the Aging Perceptions Questionnaire a multidimensional instrument for assessing self perceptions of aging Maja Barker Ann O Hanlon Hannah McGee Anne Hickey and Ronán Conroy PDF Gender differences in the presentation and management of acute coronary syndromes a national sample of 1365 admissions Frank Doyle Davida De La Harpe Hannah McGee Emer Shelley and Ronán Conroy PDF Impact of briefly assessed depression on secondary prevention outcomes after acute coronary syndrome a one year longitudinal survey Hannah McGee Frank Doyle Ronán Conroy Davida De La Harpe and Emer Shelley PDF Nine year comparison of presentation and management of acute coronary syndromes in Ireland a national cross sectional survey Frank Doyle Davida De La Harpe Hannah McGee Emer Shelley and Ronán Conroy PDF Response shift masks the treatment impact on patient reported outcomes PROs the example of individual quality of life in edentulous patients Lena Ring Stefan Hofer Frank Heuston David Harris and Ciaran O Boyle PDF Third National Survey of Cardiac Rehabilitation Service Provision in Ireland progress on the 1999 National Cardiovascular Health Strategy Recommendations Mary Delaney Rachel Flynn Marian Kiernan Frank

    Original URL path: http://epubs.rcsi.ie/2008.html (2015-10-30)
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  • "Long-term controlled delivery of rhBMP-2 from collagen-hydroxyapatite " by Elaine Quinlan, Emmet M. Thompson et al.
    of Ireland HRA POR 2011 27 Comments This article is also available at http www journals elsevier com journal of controlled release Abstract The clinical utilization of recombinant human bone morphogenetic protein 2 rhBMP 2 delivery systems for bone regeneration has been associated with very severe side effects which are due to the non controlled and non targeted delivery of the growth factor from its collagen sponge carrier post implantation which necessitates supraphysiological doses However rhBMP 2 presents outstanding regenerative properties and thus there is an unmet need for a biocompatible fully resorbable delivery system for the controlled targeted release of this protein With this in mind the purpose of this work was to design and develop a delivery system to release low rhBMP 2 doses from a collagen hydroxyapatite CHA scaffold which had previously been optimized for bone regeneration and recently demonstrated significant healing in vivo In order to enhance the potential for clinical translation by minimizing the design complexity and thus upscaling and regulatory hurdles of the device a microparticle and chemical functionalization free approach was chosen to fulfill this aim RhBMP 2 was combined with a CHA scaffold using a lyophilization fabrication process to produce a highly porous CHA scaffold supporting the controlled release of the protein over the course of 21days while maintaining in vitro bioactivity as demonstrated by enhanced alkaline phosphatase activity and calcium production by preosteoblasts cultured on the scaffold When implanted in vivo these materials demonstrated increased levels of healing of critical sized rat calvarial defects 8weeks post implantation compared to an empty defect and unloaded CHA scaffold without eliciting bone anomalies or adjacent bone resorption These results demonstrate that it is possible to achieve bone regeneration using 30 times less rhBMP 2 than INFUSE the current clinical gold standard thus this work

    Original URL path: http://epubs.rcsi.ie/anatart/81/ (2015-10-30)
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  • Beaumont Hospital - Critical Care & Anaesthetics Directorate | Royal College of Surgeons in Ireland Research | e-publications@RCSI
    Home Beaumont Hospital Critical Care Anaesthetics Directorate Beaumont Hospital Critical Care Anaesthetics Directorate Follow Enter search terms Select context to search in this collection in this repository across all repositories Advanced Search Notify me via email or RSS Browse Collections

    Original URL path: http://epubs.rcsi.ie/bhcca/ (2015-10-30)
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  • Beaumont Hospital - Intensive Care Unit | Royal College of Surgeons in Ireland Research | e-publications@RCSI
    Hospital Intensive Care Unit Follow Browse the Beaumont Hospital Intensive Care Unit Collections Intensive Care Unit Beaumont Hospital Reports Enter search terms Select context to search in this collection in this repository across all repositories Advanced Search Notify me via

    Original URL path: http://epubs.rcsi.ie/icubh/ (2015-10-30)
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  • Intensive Care Unit, Beaumont Hospital Reports | Beaumont Hospital - Intensive Care Unit | Royal College of Surgeons in Ireland
    Making end of life care central to hospital care quality standards for end of life care in hospitals Irish Hospice Foundation PDF Dying in hospital in Ireland an assessment of the quality of care in the last week of life National audit of end of life care in hospitals in Ireland 2008 9 Kieran McKeown Trutz Haase Jonathan Pratschke Shelagh Twomey Helen Donovan and Feline Engling Enter search terms Select

    Original URL path: http://epubs.rcsi.ie/icubhrep/ (2015-10-30)
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  • Beaumont Hospital - Laboratory Medicine Directorate | Royal College of Surgeons in Ireland Research | e-publications@RCSI
    Account Home Beaumont Hospital Laboratory Medicine Directorate Beaumont Hospital Laboratory Medicine Directorate Follow Enter search terms Select context to search in this collection in this repository across all repositories Advanced Search Notify me via email or RSS Browse Collections Disciplines

    Original URL path: http://epubs.rcsi.ie/bhlabmed/ (2015-10-30)
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  • Beaumont Hospital - Medicine Directorate | Royal College of Surgeons in Ireland Research | e-publications@RCSI
    My Account Home Beaumont Hospital Medicine Directorate Beaumont Hospital Medicine Directorate Follow Enter search terms Select context to search in this collection in this repository across all repositories Advanced Search Notify me via email or RSS Browse Collections Disciplines Disciplines

    Original URL path: http://epubs.rcsi.ie/bhmed/ (2015-10-30)
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  • Beaumont Hospital - Nephrology, Urology and Transplantation Directorate | Royal College of Surgeons in Ireland Research | e-publications@RCSI
    Beaumont Hospital Nephrology Urology and Transplantation Directorate Beaumont Hospital Nephrology Urology and Transplantation Directorate Follow Enter search terms Select context to search in this collection in this repository across all repositories Advanced Search Notify me via email or RSS Browse

    Original URL path: http://epubs.rcsi.ie/bhneurtr/ (2015-10-30)
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